Classification : Low molecular weight heparins

Danaparoid will inhibit the thrombin generation by inhibiting the coagulation factor Xa and thrombin ( factor IIa ).[15]

Prevention  & treatment of venous thromboembolism[8]

Prevent clotting during extracorporeal circulation ( haemodialysis )

Stabilise unstable angina

Prevention of deep-vein thrombosis in general or orthopaedic surgery[1]

Used in thromboembolic disease in patient having history of heparin-induced thrombocytopenia[1]

• Bleeding esp among low body weight adults eg men below 57kg[8]

• 
  Pain at injection site , fever[13]

i. Danaparoid-Heparinoids

Use of the two agents together will increase the risk of bleeding due to increased in Prothrombin Time (PT)[4]

Dose depends on uses

For treatment of venous thromboembolism, dose 1000 units/kg by sc injection every 12 hours until optimum anticoagulant effect[8]

For unstable angina, it is given sc of 1mg/kg or 100units/kg for every 12 hours, continue to at least a week together with aspirin[17]

Use with care in elderly and patients with renal failure; creatinine clearance < 30ml/minute[13]

Patients with recent or anticipated epidural or spinal anesthesia are at risk of spinal & epidural hemitoma and consequent paralysis when using this drug[13]

Contraindicated with patient having hemorrhagic disorder[1]

Not to be used in patient having low thrombocytes level[1]

Contraindicated in patient with diabetic retinopathy[1]

Contraindicated in patient with severe hypertension[1]